Drug information of Ibuprofen

Ibuprofen

فارسی

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). It works by reducing hormones that cause inflammation and pain in the body. Ibuprofen is used to reduce fever and treat pain or inflammation caused by many conditions such as headache, toothache, back pain, arthritis, menstrual cramps, or minor injury.

Mechanism of effect

Ibuprofen tablets contain Ibuprofen which possesses analgesic and antipyretic activities. Its mode of action, like that of other NSAIDs, is not completely understood, but may be related to prostaglandin synthetase inhibition.

Pharmacodynamic

Ibuprofen is a nonsteroidal anti-inflammatory agent (NSAIA) or nonsteroidal anti-inflammatory drug (NSAID), with analgesic and antipyretic properties. Ibuprofen has pharmacologic actions similar to those of other prototypical NSAIAs, which are thought to act through inhibition of prostaglandin synthesis.

Pharmacokinetics

~ 80% absorbed from GI tract Time to reach peak plasma concentration = 47 minutes (suspension), 62 minutes (chewable tablets), 120 minutes (conventional tablets) 90-99% to whole human plasma and site II of purified albumin, Ibuprofen is rapidly metabolized and eliminated in the urine. The serum half-life is 1.8 to 2.0 hours.

Dosage

Usual Adult Dose for Fever Oral: 200 to 400 mg orally every 4 to 6 hours as needed. IV: (Patients should be well hydrated before IV ibuprofen administration): Fever: Initial: 400 mg intravenously over 30 minutes Maintenance: 400 mg every 4 to 6 hours or 100 to 200 mg every 4 hours as needed. Usual Pediatric Dose for Fever Greater than 6 months to 12 years: 5 mg/kg/dose for temperature less than 102.5 degrees F (39.2 degrees C) orally every 6 to 8 hours as needed. 10 mg/kg/dose for temperature greater than or equal to 102.5 degrees F (39.2 degrees C) orally every 6 to 8 hours as needed. The recommended maximum daily dose is 40 mg/kg. OTC pediatric labeling (analgesic, antipyretic): 6 months to 11 years: 7.5 mg/kg/dose every 6 to 8 hours; Maximum daily dose: 30 mg/kg Usual Adult Dose for Dysmenorrhea 200 to 400 mg orally every 4 to 6 hours as needed.

Alerts

1- NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may increase with duration of use. Patients with cardiovascular disease or risk factors for cardiovascular disease may be at greater risk 2- Ibuprofen tablets are contraindicated for treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery 3- NSAIDS cause an increased risk of serious gastrointestinal adverse events including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal. These events can occur at any time during use and without warning symptoms. Elderly patients are at greater risk for serious gastrointestinal events

Points of recommendation

1-treatment with Ibuprofen tablets is not recommended in patients with advanced renal disease. 2-As with other NSAIDs, anaphylactoid reactions may occur in patients without known prior exposure to Ibuprofen tablets. Ibuprofen tablets should not be given to patients with the aspirin triad. 3-NSAIDs, including Ibuprofen tablets, can cause serious skin adverse events such as exfoliative dermatitis, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis (TEN), which can be fatal. 4-In late pregnancy, as with other NSAIDs, Ibuprofen tablets should be avoided because it may cause premature closure of the ductus arteriosus. 5-Anemia is sometimes seen in patients receiving NSAIDs, including Ibuprofen tablets. 6-Patients with asthma may have aspirin-sensitive asthma. The use of aspirin in patients with aspirin-sensitive asthma has been associated with severe bronchospasm, which can be fatal. 7-Patients should promptly report signs or symptoms of unexplained weight gain or edema to their physicians. 8-Blurred and/or diminished vision, scotomata, and/or changes in color vision have been reported. If a patient develops such complaints while receiving Ibuprofen tablets, the drug should be discontinued, and the patient should have an ophthalmologic examination which includes central visual fields and color vision testing.

Pregnancy level

C

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