Drug information of Luliconazole

Luliconazole

فارسی

Luliconazole is a topical antifungal agent that acts by unknown mechanisms but is postulated to involve altering the synthesis of fungi cell membranes.

Mechanism of effect

The exact mechanism of action for luliconazole's anti-fungal activity is still not known, but luliconazole is thought to inhibit the enzyme lanosterol demethylase. Lanosterol demethylase is needed for the synthesis of ergosterol, which is a major component of the fungus cell membranes.

Pharmacodynamic

Luliconazole kills the organisms Trichophyton rubrum and Epidermophyton floccosum, most likely by altering their fungal cell membranes.

Pharmacokinetics

Absorption

Tinea pedis

  • Peak plasma concentration: 0.4 ng/mL (first dose); 0.93 ng/mL (final dose)
  • Peak plasma time: 16.9 hr (first dose); 5.8 hr (final dose)
  • AUC: 6.88 ng•hr/mL (first dose); 18.74 ng•hr/mL (final dose)

Tinea cruris

  • Peak plasma time: 21 hr (first dose); 6.5 hr (final dose)
  • Peak plasma concentration: 4.91 ng/mL (first dose); 7.36 ng/mL (final dose)
  • AUC: 85.1 ng•hr/mL (first dose); 121.74 ng•hr/mL (final dose)

Protein bound: >99%

Dosage

Adult

Tinea Corporis

Apply cream to affected area and ~1-inch surrounding area(s) qDay for 1 week

Tinea Cruris

Apply cream to affected area and ~1-inch surrounding area(s) qDay for 1 week

Tinea Pedis

Apply cream to affected area and ~1-inch surrounding area(s) qDay for 2 weeks

Pediatric

Tinea Corporis

Indicated for the treatment of tinea corporis caused by the organisms Trichophyton rubrum and Epidermophyton floccosum

<12 years: Safety and efficacy not established

12-18 years: Apply cream to affected area and ~1-inch surrounding area(s) qDay for 1 week

Tinea Cruris

Indicated for the treatment of tinea cruris caused by the organisms Trichophyton rubrum and Epidermophyton floccosum

<12 years: Safety and efficacy not established

12-18 years: Apply cream to affected area and ~1-inch surrounding area(s) qDay for 1 week

Tinea Pedis

Indicated for the treatment of interdigital tinea pedis caused by the organisms Trichophyton rubrum and Epidermophyton floccosum

<2 years: Safety and efficacy not established

2-18 years: Apply cream to affected area and ~1-inch surrounding area(s) qDay for 2 weeks

Alerts

For topical use only; not for ophthalmic or intravaginal administration

May inhibit CYP2C19 and CYP3A4 isoenzymes; particularly when treating large surface areas (ie, moderate-to-severe tinea cruris) that result in increased luliconazole systemic exposure

Points of recommendation

  • Tell all of your health care providers that you take luliconazole. This includes your doctors, nurses, pharmacists, and dentists.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using luliconazole while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
  • Wash your hands before and after use. Do not wash your hands after use if putting this on your hand.
  • Clean affected part before use. Make sure to dry well.
  • Put a thin layer on the affected part and rub in gently.
  • To gain the most benefit, do not miss doses.
  • Use as you have been told, even if your signs get better.
  • Put on a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not put on 2 doses or extra doses.

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